Koichi Seto Selected Research

Z-360

10/2011	CCK-2/gastrin receptor signaling pathway is significant for gemcitabine-induced gene expression of VEGF in pancreatic carcinoma cells.
10/2010	Z-360, a novel therapeutic agent for pancreatic cancer, prevents up-regulation of ephrin B1 gene expression and phosphorylation of NR2B via suppression of interleukin-1 β production in a cancer-induced pain model in mice.
1/2010	Pharmacological evaluation of analgesic effects of the cholecystokinin2 receptor antagonist Z-360 in mouse models of formalin- and cancer-induced pain.
1/2010	Z-360, a novel cholecystokinin-2/gastrin receptor antagonist, inhibits gemcitabine-induced expression of the vascular endothelial growth factor gene in human pancreatic cancer cells.

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Koichi Seto Research Topics

Disease

4	Pancreatic Neoplasms (Pancreatic Cancer) 10/2011 - 01/2010
3	Neoplasms (Cancer) 03/2015 - 01/2010
2	Pain (Aches) 10/2010 - 01/2010
1	Infections 09/2020
1	COVID-19 09/2020
1	Neoplasm Metastasis (Metastasis) 01/2014
1	Lymphatic Metastasis 01/2014
1	Melanoma (Melanoma, Malignant) 01/2014
1	Carcinogenesis 10/2011
1	Hypoxia (Hypoxemia) 10/2011
1	Cancer Pain 01/2010
1	Adenocarcinoma 01/2010

Drug/Important Bio-Agent (IBA)

4	Z-360IBA 10/2011 - 01/2010
3	Gemcitabine FDA Link 10/2011 - 01/2010
3	Cholecystokinin B ReceptorIBA 10/2011 - 01/2010
2	specific substance maruyama (Z-100)IBA 03/2015 - 01/2014
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 10/2011 - 01/2010
2	Pharmaceutical PreparationsIBA 10/2010 - 01/2010
2	Analgesics (Analgesic Drugs)IBA 10/2010 - 01/2010
2	Cholecystokinin (Pancreozymin)IBA 01/2010 - 01/2010
1	AntibodiesIBA 09/2020
1	Immunoglobulin G (IgG)IBA 09/2020
1	Immunoglobulin M (IgM)IBA 09/2020
1	Granzymes (Granzyme)IBA 01/2014
1	Proteins (Proteins, Gene)FDA Link 01/2014
1	GastrinsIBA 10/2011
1	Ephrin-B1 (Ephrin B1)IBA 10/2010
1	Opioid Analgesics (Opioids)IBA 10/2010
1	Sincalide FDA Link 10/2010
1	Interleukin-1 (Interleukin 1)IBA 10/2010
1	Tyrosine (L-Tyrosine)FDA Link 10/2010
1	N-Methyl-D-Aspartate Receptors (NMDA Receptors)IBA 10/2010
1	DevazepideIBA 10/2010
1	Formaldehyde (Formol)FDA Link 01/2010
1	Cholecystokinin A ReceptorIBA 01/2010
1	Morphine (MS Contin)FDA LinkGeneric 01/2010

Therapy/Procedure

2	Therapeutics 10/2011 - 10/2010
1	Immunotherapy 03/2015
1	Intraperitoneal Injections 10/2010
1	Oral Administration 01/2010